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Bio for non majors 12

Bio for non majors 12 - – Most common secondary...

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Proteins Composed of a amino acids (polypeptide chain) 20 different amino acids The linear polypeptide chain is folded into a 3D shape How are proteins made? RNA vs. DNA Transcription RNA polymerase Unwinds the DNA Strings together a series of RNA nucleotides that is complementary to the DNA Overview of Translation Transcription and Translation Proteins are folded into complex structures Significance of Protein Structure What does structure offer in the way of biological knowledge? Identification of binding partners Enzyme mechanisms Drug design Evolutionary Relationships Levels of Protein Structure Primary Structure Secondary Structure Spatial arrangement of amino acids chemically bonded to each other
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Unformatted text preview: – Most common secondary structures: α-helix, β-strand, turns and loops • Tertiary Structure • The 3 dimensional arrangement of secondary structure elements • Quaternary Structure • The arrangement of multiple folded protein molecules (or protein subunits) into a functional multi-subunit complex • Molecular Chaperones • A proteins that guide the folding of many proteins • Abnormally folded proteins aggregate and cause human disease Huntington’s Disease • Alpha 1-antitrypsin deficiency • Prion diseases • Gene: IT15 – Contains repeats of CAG – CAG codes for the amino acid glutamine – Many glutamines in a row cause protein aggregation...
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