Bio for Non- majors 4

Bio for Non- majors 4 - A mutated proto-oncogene Mutated...

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The Cell Cycle Cancer cells do not have contact inhibition Cancer cells divide indefinitely Telomeres are long enough to support about 60 cell divisions Telomerase Cell cycle checkpoints Checkpoints ensure that each stages of the cell cycle has been completed properly before the next stage begins G1 checkpoint Ensures that cell division is triggered only when growth factors are present G2 checkpoint Ensures that DNA replication has occurred properly before mitosis begins Metaphase checkpoint Ensures that all sister chromatids are attached to microtubules of the spindle fiber before anaphase begins Genes involved in regulation of the cell cycle: Genes that green light cell division Proto-oncogene “before cancer” Encode proteins that regulate cell division Oncogene
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Unformatted text preview: A mutated proto-oncogene Mutated proteins no longer properly regulate cell division Capable of causing cancer Over-stimulate cell division Genes involved in regulation of the cell cycle: Genes that halt cell division Tumor suppressor gene Encode proteins that normally stop cell division when conditions are not favorable Key Points Cancer cells are different from normal cells Telomeres protect chromosome ends and limit the number of cell divisions Telomerase extends telomere DNA Cell cycle checkpoints ensure that the stages of the cell cycle are completed properly before continuing to divide Proto-oncogenes and tumor suppressor genes regulate the cell cycle These regulatory genes are often mutated in cancer cells...
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This note was uploaded on 11/08/2011 for the course BIO 0815 taught by Professor Crucielli during the Spring '11 term at Pittsburgh.

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