Protein Structure

Protein Structure - Amino Acids Proteins and Enzymes...

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1 Amino Acids, Proteins, and Enzymes Primary and Secondary Structure Tertiary and Quaternary Structure Protein Hydrolysis and Denaturation
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2 Primary Structure of Proteins The particular sequence of amino acids that is the backbone of a peptide chain or protein H 3 N CH CH 3 C O N H CH C O N H CH C O N H CH C O - O CH CH CH 3 CH 3 CH 2 SH CH 2 CH 2 S CH 3 + Ala-Leu-Cys-Met
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3 Secondary Structure – Alpha Helix Three-dimensional arrangement of amino acids with the polypeptide chain in a corkscrew shape Held by H bonds between the H of –N-H group and the –O of C=O of the fourth amino acid along the chain Looks like a coiled “telephone cord”
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4 Secondary Structure – Beta Pleated Sheet Polypeptide chains are arranged side by side Hydrogen bonds form between chains R groups of extend above and below the sheet Typical of fibrous proteins such as silk
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5 Secondary Structure – Triple Helix Three polypeptide chains woven together Glycine, proline, hydroxy proline and hydroxylysine H bonding between –OH groups gives a strong structure Typical of collagen, connective tissue, skin, tendons, and cartilage
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6 Learning Check P1
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