Ch 43 %28doc%291 - CHAPTER 43 Slide: 1 The Immune System...

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CHAPTER 43 Slide: 1 The Immune System Chapter 43 Slide: 2 Immune System A collection of biological structures (cells, tissues, organs) and processes within an organism that help protects against disease by removing pathogens and abnormal cells Figure 43.7 (Campbell 8th ed) Slide: 3 Immune System Pathogen = disease causing microorganisms, viruses and fungi e.g. Macrophage eats Sreptococcus bacteria e.g. Macrophage eats virus e.g. Macrophage eats Candida albicans (a fungus) e.g. Liver smear of Macrophage with Plasmodium spp Slide: 4 The Immune System Innate Immunity 1° defense Nonspecific Fast External innate defenses - try to prevent entry of pathogen Internal innate defenses - - fight pathogen once inside Innate immunity occurs in plants, Invertebrates, Vertebrates Acquired Immunity 2° defense Specific Slower Cell-mediated response - cytotoxic cells (lymphocytes) Humoral response - antibodies in body fluids Acquired immunity occurs only in jawed Vertebrates Refer to Figure 43.2 (Campbell 8th ed) and text Slide: 5 Innate Immunity External Defenses Skin and exoskeleton A physical barrier to prevent pathogens from entering body Slide: 6 Innate Immunity External Defenses Ciliated epithelia Secretions e.g. mucus Mucus cell Ciliated cells
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Slide: 7 Innate Immunity External Defenses Secretions Many secretions are antibacterial due to lysozyme (an enzyme) e.g. saliva, tears, breast milk (NOT lysoSOme, which is an organelle) Slide: 8 Innate Immunity External Defenses Secretions – antibacterial (acidic) Other secretions are antibacterial due to being acidic e.g. Slide: 9 Innate Immunity Internal Defenses Phagocytosis Antimicrobial peptides Inflammation - Only in vertebrates Natural Killer (NK) cells - Only in vertebrates White blood cell (WBC) (aka lymphocyte) is a brood name for 5-7 types of cells of the immune system; Pluripotent stem cell → (Multipotent) Hematopoietic stem cell Lymphoid stem cell → Lymphocytes (B and T) NK cell** Myeloid stem cell → RBCs, platelets, & several WBCs (baso-, eosino- & neutrophils, monocytes (which become macrophages**, mast cells**) **not in Figure 42.19 (Campbell 8 th ed) Figure 42.19 (Campbell 8th ed) Slide: 10 Innate Immunity Internal Defenses WBCs have special transmembrane proteins (toll-like receptors (TLR)) that bind to certain molecules on a pathogen’s surfaces; This recognition of the pathogen initiates internal defenses (phagocytosis, antimicrobial peptides, inflammation, NK cells) Some TLRs are within the WBC outer membrane, others are in membranes of vesicles; TLRs are nonspecific, binding to cell surface molecules which don’t occur in animals cells but which are common to a group of pathogens (e.g. bacteria in general, not a specific bacteria type).
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This note was uploaded on 11/08/2011 for the course BSC 2011C taught by Professor Klowden/crampton during the Fall '11 term at University of Central Florida.

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Ch 43 %28doc%291 - CHAPTER 43 Slide: 1 The Immune System...

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