CYTOMOBILITY2009 - Cell Motility Motility A Crowning...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Cell Motility
Background image of page 2
Motility – A Crowning Achievement of Evolution
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Cytoskeleton is Dynamic Platelet: different shapes during the clotting process; resting, exposed to clotting agents; during clotting RX; based on changes in the actin cytoskeleton.
Background image of page 4
Components of a Motility System A protein that undergo a conformational change i.e the motor An energy source – ATP – can bind to motor A substratum of polarized filaments A pattern of change in the motor characterized by power and recovery phases Cargo – vesicles, chromosomes, organelles
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Major Motility Systems Microtubule-based movements: motors are kinesins and dyneins (MAPS); fast axonal transport, movement of cell appendages Microfilament-based movements: motors are the myosins (muscle contraction) All use ATP as an energy source. Movement is effected by ATP hydrolysis and alteration in the shape of the motor protein
Background image of page 6
Motors : Machines That Convert Chemical or Electrical Energy Into Mechanical Energy
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
The Kinesin Motor Globular head – ‘foot’attaches to MT; site of hydrolysis Coiled helical region Tail region – light chain region attaches to vesicle or organelle Moves toward +end of MT – senses polarity Cytosolic; spindle
Background image of page 8
Dynein Minus-End Directed Motor
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Different Motors Transport Different Cargos Along MTs
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 40

CYTOMOBILITY2009 - Cell Motility Motility A Crowning...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online