CYTOMOBILITY2009 - Cell Motility Motility A Crowning...

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Cell Motility
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Motility – A Crowning Achievement of Evolution
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The Cytoskeleton is Dynamic Platelet: different shapes during the clotting process; resting, exposed to clotting agents; during clotting RX; based on changes in the actin cytoskeleton.
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Components of a Motility System A protein that undergo a conformational change i.e the motor An energy source – ATP – can bind to motor A substratum of polarized filaments A pattern of change in the motor characterized by power and recovery phases Cargo – vesicles, chromosomes, organelles
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Major Motility Systems Microtubule-based movements: motors are kinesins and dyneins (MAPS); fast axonal transport, movement of cell appendages Microfilament-based movements: motors are the myosins (muscle contraction) All use ATP as an energy source. Movement is effected by ATP hydrolysis and alteration in the shape of the motor protein
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Motors : Machines That Convert Chemical or Electrical Energy Into Mechanical Energy
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The Kinesin Motor Globular head – ‘foot’attaches to MT; site of hydrolysis Coiled helical region Tail region – light chain region attaches to vesicle or organelle Moves toward +end of MT – senses polarity Cytosolic; spindle
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Dynein Minus-End Directed Motor
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Different Motors Transport Different Cargos Along MTs
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