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Cytoplasmic Membrane SystemsI07

Cytoplasmic Membrane SystemsI07 - Cytoplasmic Membrane...

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Cytoplasmic Membrane Systems I
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Eukaryotic Cells Contain Distinct Membrane-Bound Compartments Note the variety of membrane organelles. Which belong to the endomembrane sytem? Which do not? Intestinal epithelial cell; note microvilli and polarity of cell
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Membrane bounded organelles
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Origin of Compartments in the Eucaryotic Cell
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The Endomembrane System Dynamic, integrated, ordered membrane bound Nucleus, ER, Golgi, lysosomes, endosomes, vesicles Best illustrated by biosynthetic and secretory pathways of the cell Functions: protein (and lipid) synthesis, processing, sorting and packaging for specific target sites.
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Overview of cell’s biosynthetic/secretory and endocytic pathways
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Summary Cells have complicated pathways ( TRAFFIC PATTERNS) by which materials are transported to and removed from membrane compartments Proteins – (soluble, secretory, membrane) are targeted to specific sites within or outside of the cell. SORTING/TARGETING: proteins have a specific address or signal encoded in the amino acid sequence or attached oligosaccharide that tell them where to go
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The Pancreatic Cell and Pulse- Chase Experiments
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Autoradiography and EM Reveal the site of synthesis and subsequent transport of secretory proteins from the exocrine portion of the pancreas Labeled here is the endoplasmic reticulum
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What is the Fate of the Labeled Protein in the Pancreatic Cell?
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