Cytoplasmic Membrane SystemsI07

Cytoplasmic Membrane SystemsI07 - Cytoplasmic Membrane...

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Unformatted text preview: Cytoplasmic Membrane Systems I Eukaryotic Cells Contain Distinct Membrane-Bound Compartments Note the variety of membrane organelles. Which belong to the endomembrane sytem? Which do not? Intestinal epithelial cell; note microvilli and polarity of cell Membrane bounded organelles Origin of Compartments in the Eucaryotic Cell The Endomembrane System Dynamic, integrated, ordered membrane bound Nucleus, ER, Golgi, lysosomes, endosomes, vesicles Best illustrated by biosynthetic and secretory pathways of the cell Functions: protein (and lipid) synthesis, processing, sorting and packaging for specific target sites. Overview of cells biosynthetic/secretory and endocytic pathways Summary Cells have complicated pathways ( TRAFFIC PATTERNS) by which materials are transported to and removed from membrane compartments Proteins (soluble, secretory, membrane) are targeted to specific sites within or outside of the cell. SORTING/TARGETING: proteins have a specific address or signal encoded in the amino acid sequence or attached oligosaccharide that tell them where to go The Pancreatic Cell and Pulse- Chase Experiments Autoradiography and EM Reveal the site of synthesis and subsequent transport of secretory proteins from the exocrine portion of the pancreas Labeled here is the endoplasmic reticulum What is the Fate of the Labeled Protein in the Pancreatic Cell?Protein in the Pancreatic Cell?...
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Cytoplasmic Membrane SystemsI07 - Cytoplasmic Membrane...

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