thecytoskeleton07rev

thecytoskeleton07rev - The Cytoskeleton The Cytoskeleton...

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Unformatted text preview: The Cytoskeleton The Cytoskeleton …What Is It? • A 3-D proteinaceous and fibrous matrix in the cytosol • Major filaments are microtubules (MTs), microfilaments (MFs),and intermediate filaments (IMFs); (size differences) • A complex of proteins may be associated with filaments • Difficult to study; special methods required Actin Network in a Spreading Platelet Cryoelectron images – lamellipodium showing actin filaments, microtubules and ribosomes – see last image lower right panel Functions of the Cytoskeleton • Provides scaffold for structural support • Positions organelles in the cell • Responsible for intracellular movement of organelles and other materials • Force-generating mechanisms to move cells or parts of organism • Anchors mRNA; facilitates translation • Movement of chromosomes, cytokinesis Immunofluorescence microscopy Cultured Epithelial Cell • Green = microtubules • Blue = chromatin • Red = Filamentous actin Features of Microtubules • Tubular, 25 nm in x-section • Relatively stiff but flexible; length varies • Composed of 13 protofilaments • Each protofilament a linear array of tubulin – tubulin consists of alpha-beta subunits; domains • Display polarity; uniform orientation of tubulin dimers • Very dynamic; grow and shrink • Axonemal and cytoplasmic microtubules Microtubule Function • Internal scaffolding for support; resist...
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This note was uploaded on 11/09/2011 for the course CELL BIO & 270 taught by Professor Hart during the Fall '08 term at Rutgers.

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thecytoskeleton07rev - The Cytoskeleton The Cytoskeleton...

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