2Electrical+SignalsTRACS

2Electrical+SignalsTRACS - Electrical Signals of Nerve...

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Electrical Signals of Nerve Cells
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Electrical Transmission Neurons are poor conductors Axons as wires Electrical signaling in neurons is based on potential differences across the membrane The question is “How can potential differences across membranes be used to signal over long distances?”
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+++++++++++++++ - - - - - - - - - - - - - - - Membrane Potential (V m ) • What is V m ? How is it measured?
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Changes in V m Passive changes and action potentials Natural or Experimental
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Resting Membrane Potential Underlying principles Concentration differences in ions due to action of ion pumps Differential permeability of membrane due to ion channels
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Free Energy The change in free energy associated with ion movement has two components One associated with moving in a concentration gradient One associated with moving in a charge gradient G IonMovement = D G C + D G V
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X o X i Change in Free Energy Assoc’d w/Concentration Gradient Written like a chemical equation, X o --> X i G = RT ln [ X ] i [ X ] o + RT ln K eq 0 G C = RT ln [ X ] i [ X ] o
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2Electrical+SignalsTRACS - Electrical Signals of Nerve...

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