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4ChannelsPumpsTRACS - Channels and Pumps Ion Channels...

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Channels and Pumps
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Ion Channels Involved in Propagating APs Characteristics of channels postulated by Hodgkin and Huxley to be responsible for conductances discovered in voltage-clamp experiments: Rapid kinetics Selectivity for respective ions (Na + and K + ) – Sensitivity to changes in V m
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Patch Clamp Technique Neher and Sakmann, Max Planck Institute, Göttingen, Germany Allows currents through individual channels to be assessed as well as currents through populations of channels.
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Micro- and Macroscopic Currents Experimental evidence in support of Rapid kinetics Selectivity for respective ions (Na + and K + ) –Sensitivity to changes in V m
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What does a picoamp current present in terms of ion flow? 1 ampere = 1 coulomb/sec 1 picoamp = 1X10 -12 amp Each electron carries 1.6X10 -19 coulombs of charge 10 - 12 coulombs sec * electron 1.6 ´ 10 - 19 coulombs = 6.25 ´ 10 6 electrons sec
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Ion Channels in General Integral membrane proteins which form a pore through the lipid bilayer Selectivity Gating
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Molecular Diversity and Structure of V-gated Channels
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4ChannelsPumpsTRACS - Channels and Pumps Ion Channels...

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