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6SynaptictransmissionTRACS

6SynaptictransmissionTRACS - Synaptic Transmission What...

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Synaptic Transmission What happens when an action potential reaches the synaptic bouton?
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Two major types of synapses Electrical and Chemical
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Electrical Synapses Structure Gap junctions between cells Presynaptic cells is structurally indistinguishable from post-synaptic cell
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Gap junctions Site where two cells come in close contact, but still have a gap (3.5 nm space) between them Characterized by presence of connexons Aqueous channels formed from six subunits of connexi n Permit passage of current and polar or charged molecules smaller than 1000 Da.
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Function Very rapid transmission of electrical signal from cell to cell.
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Chemical Synapses Structural features Presynaptic cell has synaptic vesicles Postsynaptic cell has neurotransmitter receptors Synaptic cleft = space separating pre- and post-synaptic cells
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Studying the Chemical Synapse Fatt and Katz Model system = Neuromuscular Jxn Advantages Accessible Muscle is amenable to intracellular recording and excitable Disadvantages Electrode can be dislodged during contraction Solution: Lower Ca ++ use curare (NTR block)
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Experimental Set-up
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