8NTRsIntracellularSignaling

8NTRsIntracellularSignaling - Neurotransmitter Receptors...

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Unformatted text preview: Neurotransmitter Receptors and Intracellular Signaling How does an extracellular signal generate a post- synaptic response? Two Major Types of NTR Ionotropic Ligand-gated ion channels Metabotropic G-protein coupled receptors Examples of Ionotropic Receptors Nicotinic acetylcholine receptor Certain glutamate receptors Kainate receptor AMPA receptor NMDA receptor Glycine receptors GABA receptors Excitatory Inhibitory Structure of Ionotropic Receptors Integral membrane proteins Multiple subunits Ligand-binding domain Pore-forming elements General Structure of Channels Typically 4 or 5 subunits Electron micrograph Nicotinic AChR Cation channel Mainly conducts an inwardly directed, Na + current (but can also conduct an outwardly directed K + current ) Patch clamp experiments Neher and Sakmann mid-70s What determines current carried by nAChR? Ohms law V = IR I = V R I = gV I X = g X [ V m- E X ] Lower Na + o Elevated K + o Summary of nAChRs at NMJ Ligand-gated ion channels Physiologically, the dominant current is an inwardly directed Na + current Na + current leads to depolarization of muscle cell Depol. leads to activation of v-g channels Activation leads to AP Ionotropic Glutamate...
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8NTRsIntracellularSignaling - Neurotransmitter Receptors...

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