8NTRsIntracellularSignaling

8NTRsIntracellularSignaling - Neurotransmitter Receptors...

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Unformatted text preview: Neurotransmitter Receptors and Intracellular Signaling How does an extracellular signal generate a post- synaptic response? Two Major Types of NTR • Ionotropic – Ligand-gated ion channels • Metabotropic – G-protein coupled receptors Examples of Ionotropic Receptors • Nicotinic acetylcholine receptor • Certain glutamate receptors – Kainate receptor – AMPA receptor – NMDA receptor • Glycine receptors • GABA receptors Excitatory Inhibitory Structure of Ionotropic Receptors • Integral membrane proteins • Multiple subunits • Ligand-binding domain • Pore-forming elements General Structure of Channels Typically 4 or 5 subunits Electron micrograph Nicotinic AChR • Cation channel • Mainly conducts an inwardly directed, Na + current (but can also conduct an outwardly directed K + current ) Patch clamp experiments • Neher and Sakmann mid-70’s What determines current carried by nAChR? • Ohm’s law V = IR I = V R I = gV I X = g X [ V m- E X ] Lower Na + o Elevated K + o Summary of nAChR’s at NMJ • Ligand-gated ion channels • Physiologically, the dominant current is an inwardly directed Na + current • Na + current leads to depolarization of muscle cell • Depol. leads to activation of v-g channels • Activation leads to AP Ionotropic Glutamate...
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This note was uploaded on 11/09/2011 for the course CHEM 2341 taught by Professor Staff during the Fall '11 term at Texas State.

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8NTRsIntracellularSignaling - Neurotransmitter Receptors...

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