Lecture 9 - 9 Information Transfer II – Gene...

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Unformatted text preview: 9. Information Transfer II – Gene Structure & Expression – Part II. Iain McKinnell – Dept Biology TCAGCGT AGUCGCA AGTCGCA 5’ 5’ 3’ 3’ (coding strand) (template strand) 5’ 3’ mRNA Gene Transcription RNA sequence is the same as that of the coding strand of DNA except that U replaces T mRNA is built in a 5’- 3’ direction, by reading the template strand in a 3’- 5’ Translation Overview tRNA Structure Transfer RNAs ( tRNA ) Bring specific amino acids to ribosome Cloverleaf shape Bottom end of tRNA contains anticodon sequence that pairs with codon in mRNAs Aminoacylation Ribosomes Made of ribosomal RNA (rRNA) and proteins Two subunits: large and small Translation Stages Initiation Ribosome assembled with mRNA molecule and initiator methionine-tRNA Elongation Amino acids linked to tRNAs added one at a time to growing polypeptide chain Termination New polypeptide released from ribosome Ribosomal subunits separate from mRNA Initiation (1) Initiator tRNA (Met-tRNA) binds to small subunit Initiation (2) Complex binds to 5´ cap of mRNA, scans along mRNA to find AUG start codon Prokaryotes – no scanning Initiation (3) Large ribosomal subunit binds to complete initiation Elongation (1) Aminoacyl-tRNA matching the next codon enters...
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This note was uploaded on 11/08/2011 for the course BIOL 1103 taught by Professor Mckinnel during the Fall '11 term at Carleton CA.

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Lecture 9 - 9 Information Transfer II – Gene...

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