Lecture 10 - 10. Information Transfer III Control of gene...

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10. Information Transfer III Control of gene expression. Iain McKinnell Dept Biology
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Regulation of Gene Expression in Prokaryotes the Operon: Unit of Transcription Prokaryotic gene expression reflects life history Rapid, reversable response to environment Operon : A cluster of prokaryotic genes and DNA sequences involved in their regulation RNA polymerase binds at promoter for operon Many genes may be transcribed into one mRNA Cluster of genes is transcription unit
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Several regulatory elements may be important in prokaryotic gene expression Other regulatory DNA sequence in operon is the operator Regulatory protein coded by gene outside operon Repressor proteins prevent operon genes from being expressed Activator proteins turn on expression of genes from operon Positive regulatory
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Other regulatory DNA sequence in operon is the operator Regulatory protein coded by gene outside operon Repressor proteins prevent operon genes from being expressed Activator proteins turn on expression of genes from operon Positive regulatory STOP Several regulatory elements may be important in prokaryotic gene expression
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Other regulatory DNA sequence in operon is the operator Regulatory protein coded by gene outside operon Repressor proteins prevent operon genes from being expressed Activator proteins turn on expression of genes from operon Positive regulatory GO Several regulatory elements may be important in prokaryotic gene expression
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lac Operon for Lactose Metabolism Lactose metabolism in E. Coli requires three genes lacZ , lacY and lacA lac operon contains all three genes and regulatory sequences lac operon operator sequence is between promoter and lacZ
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E. coli lac Operon β -Galactosidase H H
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Regulation of Inducible lac Operon
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Regulation of Inducible lac Operon The lac operon for lactose metabolism is transcribed when an inducer inactivates a repressor
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This note was uploaded on 11/08/2011 for the course BIOL 1103 taught by Professor Mckinnel during the Fall '11 term at Carleton CA.

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Lecture 10 - 10. Information Transfer III Control of gene...

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