BE 167L Lecture 7 General

BE 167L Lecture 7 General - BE 167L Bioengineering Lab...

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BE 167L – Bioengineering Lab Lecture 7
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Today Cell Mechanobiology Basic mechanics Mechanical measurement techniques Physiological relevance and response to force “Mechanical” machinery of cells Case Study 3: mechanics and differentiation Case Study 4: cell-contact/mechanics and differentiation
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Mechanics – briefly… Normal Stress ε σ E = Young’s Modulus (or Stiffness) Strain Stress σ
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Tools for Mechanical Measurements Kim et al. Ann Rev Biomed Eng 2009
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Cell Mechanics and the Microenvironment
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Mechanical Environments Connective tissue - fibroblasts Cartilage - chrondrocytes Bone - osteoblasts Blood vessels - endothelial cells, smooth muscle cells What mechanical forces do they feel?
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Mechanical Elements in the Cell Cytoskeleton Motor proteins - myosins, kinesins, dynein Larger scale mechanical structures: Filopodia, lamellipodia Focal adhesions – connection to ECM Mechanotransduction – transducing force into biochemical signals
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BE 167L Lecture 7 General - BE 167L Bioengineering Lab...

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