immuneimages - Immune System Immunity the ability to resist...

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Immune System • Immunity – the ability to resist… A functional system?
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Innate Immunity • Recognizes and destroys. • Response does not… • Barriers • Cells and chemicals
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• Recognizes and destroys. .. • Response has no: – S – M – I Adaptive Immunity
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Barriers – Skin • Awesome • Stratified • Keratinized • Sweat • Sebum.
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Barriers – Body Fluids • Wash „em away. • Lysozyme
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Barriers – Mucosae • Line • All are potential… • Mucus • Acid • Lysozyme
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Specific Example Respiratory Mucosa • Mucociliary escalator Other respiratory events
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Neutrophils • Small phagocytes. • Kill… • They‟re #1
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Macrophages • Large cells derived from… • Specialize in… • “Free” vs. “Fixed”
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Lysosome Phagosome (phagocytic vesicle) Acid hydrolase enzymes 1 Phagocyte adheres to pathogens or debris. 2 Phagocyte forms pseudopods that eventually engulf the particles forming a phagosome. 3 Lysosome fuses with the phagocytic vesicle, forming a phagolysosome. 4 Lysosomal enzymes digest the particles, leaving a residual body. 5 Exocytosis of the vesicle removes indigestible and residual material. Phagocytosis
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• Phagocytosis is more likely if the microbe is adorned. Opsonization
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Natural Killer Cells • Specialized type of lymphocyte. • Attack and kill… How do they know?
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Interferons • Proteins released by… • Diffuse to… • Function
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Virus New viruses DNA mRNA Nucleus Interferon 2 3 4 5 Virus enters cell. Interferon genes switch on. Cell produces interferon molecules. Interferon binding stimulates cell to turn on genes for antiviral proteins. Antiviral proteins block viral reproduction. 1 Interferons
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• Plasma proteins. • Made by the…
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immuneimages - Immune System Immunity the ability to resist...

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