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Unformatted text preview: CO 2 + H 2 O H 2 CO 3 H + + HCO 3 Following their formation in the red blood cells, most H + bind to hemoglobin molecules (causing the Bohr effect) while the remaining H + diffuse back into the plasma, slightly decreasing the pH of the plasma. The HCO 3 ions diffuse back into the plasma as well. To balance the overall increase in negative charges entering the plasma, chloride ions diffuse in the opposite direction, from the plasma to the red blood cells (chloride shift)....
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- Spring '10