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Unformatted text preview: cells of the juxtaglomerular apparatus detect a decrease in blood pressure in the afferent arteriole or a decrease in solute (Na + and Cl ) concentrations in the distal tubule, they secrete the enzyme renin. Renin converts angiotensinogen (a plasma protein produced by the liver) to angiotensin I. Angiotensin I in turn is converted to angiotensin II by the angiotensin-converting enzyme (ACE), an enzyme produced principally by capillary endothelium in the lungs. Angiotensin II circulates in the blood and increases GFR by doing the following: Constricting blood vessels throughout the body, causing the blood pressure to rise Stimulating the adrenal cortex to secrete aldosterone, a hormone that increases blood pressure by decreasing water output by the kidneys...
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- Spring '10