NIGMS0443826

NIGMS0443826 - Collaborative Research Modeling the Growth...

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Collaborative Research: Modeling the Growth and Adhesion of Collaborative Research: Modeling the Growth and Adhesion of Auricular Chondrocytes under Controlled Flow Conditions Auricular Chondrocytes under Controlled Flow Conditions Department of Mathematics, University of Houston 1 , The Texas Heart Institute and the UT Health Science Center at Houston 2 , Baylor College of Medicine 3 and Rice University Suncica Canic 1 , Roland Glowinski 1 , Tsorng-When Pan 1 , Doreen Rosenstrauch 2 , Craig Hartley 3 (PIs) DMS-0443826 (UH), DMS-0443549(THI),   DMS-0443563(Baylor)  www.math.uh.edu/~canic/NIGMS.html RESULTS: Coronary artery disease causes narrowing or  stenosis of coronary arteries which might lead to heart attack.  Treatment of coronary artery disease involves inserting a vascular  stent into the diseased artery to keep the artery open thereby  securing blood supply to the heart muscle.  Upon implantation, vascular stents have been shown to activate  inflammatory responses due to their poor biocompatibility. To  improve biocompatibility of implantable cardiovascular devices,  our group showed that lining stents with ear cartilage cells called  auricular chondrocytes, might produce a long-lasting  biocompatible device. Chondrocytes were genetically modified to  produce nitric oxide which is known to have an anti-inflammatory  action. They were shown to exhibit superior adherance to artificial  surfaces such as those of stents, shown in Figure 2.  Figure 2. Stent struts lined with
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NIGMS0443826 - Collaborative Research Modeling the Growth...

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