Wyatt - What does mathematics contribute to bioinformatics?...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
What does mathematics What does mathematics contribute to bioinformatics? contribute to bioinformatics? Winfried Just Winfried Just Department of Mathematics Department of Mathematics Ohio University Ohio University
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A new microscope and a new A new microscope and a new physics physics In 2004 PLoS Biology published a paper by Joel E. Cohen Mathematics Is Biology's Next Microscope, Only Better; Biology Is Mathematics' Next Physics, Only Better. Really? How does this new microscope differ from the traditional ones? How to use it? Why did mathematicians become seriously interested in biology? And how is all this related to bioinformatics?
Background image of page 2
More empirical observations More empirical observations NSF and NIH recently started to invest heavily in biomathematics. In 2002 the Mathematical Biosciences Institute (MBI, located at OSU) was founded; this is the first and so far only NSF institute dedicated exclusively to applications of mathematics in one other area. Several other new research institutes in biomathematics are supported from public or private sources. A number of new journals specializing in biomathematics got started. The job market for biomathematicians is currently rather favorable, both in academia and industry, especially in the pharmaceutical industry.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What is behind this What is behind this trend? trend? And why do we observe this trend now, instead of 30 years ago or 30 years from now? There are two main reasons: 1. Contemporary biology generate a huge mountains of data. Drawing biologically meaningful inferences from these data requires analysis in the framework of good mathematical models. Hence mathematics has become a necessary tool for biology. 2. Currently available computer power allows us to investigate sufficiently detailed mathematical models to draw biologically realistic inferences. Thus mathematics has become a useful tool for biology.
Background image of page 4
Biomathematics Biomathematics vs. vs. bioinformatics bioinformatics Everything that has been said so far about “biomathematics” could also be said about “bioinformatics.” What is the difference between the two areas? Biomathematics: Applications of mathematics to biology. Bioinformatics: The design, implementation, and use of computer algorithms to draw inferences from massive sets of biomolecular data. It is an interdisciplinary field that draws on knowledge from biology, biochemistry, statistics, mathematics, and computer science.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Example of a huge data set : : Genbank Genbank The first viral genome was published in the 1980’s, the first bacterial genome, H. influenzae, 1.83 · 10 6 bp, in 1995, The first genome of a multicellular organism, C. elegans, 10 8 bp, w 1998. The sketch of our own genome, H. sapiens, π · 10 9 bp, was announced in June 2000. As of February 2008, Genbank contained 85 759 586 764 bp
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/11/2011 for the course MATH 220 taught by Professor Kearn during the Fall '11 term at BYU.

Page1 / 20

Wyatt - What does mathematics contribute to bioinformatics?...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online