Cartilage 2009 - 1 Cartilage 2010 Cartilage is a...

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1 Cartilage 2010 Cartilage is a specialized form of CT. Blood, bone, adipose tissue, reticular tissue (found in bone marrow, lymph nodes and spleen), and mucous tissue (found in the umbilical cord) are other types of specialized CT. All these specialized CT, as well as CT proper, are characterized by the varying proportions of the ground substance, fibers, and cells. Cartilage is characterized by an extracellular matrix (ground substance) rich in glycosaminoglycans (GAGs), and proteoglycans. The GAGs are mostly chondroitin sulfate and hyaluronic acid . Within this matrix are collagen Type II fibers and elastic fibers. Cartilage cells are either chondroblasts or chondrocytes. Chondros is the Greek word for cartilage. So, chondroitin sulfate was named because of its abundance in cartilage. Type II collagen fibers are also found in abundance in cartilage. This does not mean that other collagen fibers and other GAGS are not found in cartilage, but the characterizing matrix of cartilage consists of chondroitin sulfate with Type II collagen fibers imbedded in the ground substance Cartilage is relatively stiff and solid; it is more flexible and resilient than bone. It has a consistency like firm and thick jello. It is very viscous. Both GAGS and proteoglycans are enormously hydrated (bind water). These physical properties, viscous, stiffness, jello-like, are due to the hydrated GAGS and proteoglycans extracellular matrix. The collagen fibers impart tensile strength to cartilage, just like they do in all types of CT During fetal development, cartilage plays a major role in the development of the axial skeleton but, after post natal growth ceases, cartilage is found in only a few places in the body. Cartilage is avascular like epithelium. Therefore, nutrients and oxygen must diffuse in from capillaries outside the cartilage. Capillaries in the perichondrium must supply all the nutrients, including oxygen, to the
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2 cartilage cells that maybe deeply embedded in the matrix far from the perichondrium. These nutrients must diffuse through matrix to reach these chondrocytes. This lack of a blood supply means cartilage grows and repairs itself more slowly than other CT issues except in young children. Three types of cartilage are present in our bodies. A. Hyaline cartilage is the most common. It is found in the articular surface of bones, in the nose, larynx, trachea, bronchi, and it forms the articular surface of the ribs where they join the sternum. In routine slides stained with H&E, the matrix hyaline cartilage appears pale blue. B.
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Cartilage 2009 - 1 Cartilage 2010 Cartilage is a...

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