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Renin Angiotensinogen - ACE is made by endothelial...

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Renin, Angiotensin, Aldosterone Renin is a peptide hormone secreted by the juxtaglomerular (JG) cells in the afferent arterioles of the glomeruli of the kidney (renes is L. for kidneys). It is secreted in response to low blood pressure, decreased blood volume or low serum sodium Angiotensinogen is a protein that is constantly being made by the liver. When renin encounters angiotensinogen in the plasma, it cleaves some amino acids off angiotensinogen to form angiotensin I. Angiotensin I is not an active hormone but when it encounters angiotensin converting enzyme (ACE) in the plasma, it is “converted” into angiotensin II.
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Unformatted text preview: ACE is made by endothelial cells (those simple squamous inconspicuous cells that line blood vessels) throughout the body but especially in the lung. Angiotensin II is a potent vasoconstrictor (more potent than serotonin from platelets) but it also stimulates cells in the zona glomerulosa of the adrenal glands to synthesize and secrete aldosterone. (Angiotensin II influences the zona glomerulosa much more than ACTH from the anterior pituitary). Angiotensin II also helps sodium reabsorption in the proximal convoluted tubule of the kidney. Aldosterone – see my notes on Urinary Tract ....
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