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Unformatted text preview: Pathway IV: Transcytosis. Several proteins move out of the capillaries, bind to receptors on the basal membrane, enter the alveolar cell by endocytosis, are transported to apical membrane, and secreted into lumen (milk) exocytosis. In the diagrams above, note the plasma cells that make IgA antibodies. These antibodies are transcytosed across the alveolar cells to be secreted into the lumen (milk). (This is the same process that we saw in the parotid gland, GI tract, GU, and respiratory tract: IgA is the mucosal protecting antibody). Pathway V. Paracellular: During lactation, the tight junctions are intact and do not allow paracellular movement except immune cells may move into milk by diapedesis through the intercellular spaces. During involution of the breast following lactation or in the event of mastitis (inflammation), the tight junctions become very leaky....
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This note was uploaded on 11/08/2011 for the course SCIENCE 3254 taught by Professor Dr.shoupe during the Spring '11 term at Fort Valley State University .
- Spring '11