Cell - Cell ‐ Mediated Immunity(CMI Cell-mediated...

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Unformatted text preview: Cell ‐ Mediated Immunity (CMI) Cell-mediated immunity depends upon the activity of T-lymphocytes. T-lymphocytes have a longer life span than B-lymphocytes and are found in the same lymphatic tissues as the B-lymphocytes. The T-lymphocytes react with certain antigenic determinants and become immunologically “committed.” Part of this commitment is the conversion to a subset of cells called cytotoxic T- lymphocytes. Activity of cytotoxic T-lymphocytes. Cytotoxic T-lymphocytes do not produce antibody molecules. Rather, they leave the lymphatic tissues and enter the circulation. They circulate through the blood vessels and gather at the infection site. Here they interact directly with organisms such as fungi, protozoa, cancer cells, and transplant cells. They also interact with virus-infected cells and bacteria-infected cells (such as lung cells infected with tuberculosis). The T-lymphocytes exert a bacteria-infected cells (such as lung cells infected with tuberculosis)....
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  • Fall '07
  • CMI, lymphatic tissues, B­lymphocytes, cytotoxic T­lymphocytes. Cytotoxic, T­lymphocytes. T­lymphocytes

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