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Unformatted text preview: Immune complex disease. Immune complexes are combinations of antigen and antibody that have the ability to fix complement. The antibodies involved are IgM or IgG, and the antigens exist in fluid as soluble antigens. Proteins or nucleic acids may be involved. An example of immune complex hypersensitivity is serum sickness. In this condition, animal serum is administered to humans, and its proteins elicit antibody production. When the antibodies and antigens unite, they form immune complexes, which activate the complement system and cause local tissue damage. The patient may display edema of the hands, face, and feet, as well as swelling of the upper respiratory tissues and impairment of normal respiration. An inflammatory response results. Formation of immune complexes is also involved with numerous diseases including systemic lupus erythematosus, rheumatoid arthritis, and glomerulonephritis. Immune complex hypresensitivity is erythematosus, rheumatoid arthritis, and glomerulonephritis....
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This note was uploaded on 11/11/2011 for the course BIO 101 taught by Professor Pesthy during the Fall '07 term at Texas State.
- Fall '07