Pharmaceutical Products Gene defects in humans can lead to deficiencies in proteins, such as insulin, human growth hormone, and Factor VIII that may result in problems, such as diabetes, dwarfism, and impaired blood clotting, respectively. Proteins for these chemicals can now be replaced by proteins manufactured through biotechnology. For insulin production, two protein chains are encoded by separate genes in plasmids inserted into bacteria. The protein chains are then chemically joined to form the final insulin product. Human growth hormone is also produced within bacteria, but special techniques are used because the bacteria do not usually produce human proteins. Therapeutic proteins, such as the following, can also be produced by biotechnology: • Tissue plasminogen activator (TPA) , a clot-dissolving protein, can now be produced in recombined mammalian cells.
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This note was uploaded on 11/11/2011 for the course BIO 101 taught by Professor Pesthy during the Fall '07 term at Texas State.