lec1_2 - MIT 20.109 Module 1 Class 2 notes (DRAFT) 13...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: MIT 20.109 Module 1 Class 2 notes (DRAFT) 13 September 2007 Genome Engineering Drew Endy ( http://mit.edu/endy/ ) Questions Introduced Last Time A. What can we infer about the design of a genome by considering the physical problems that a biological systems solves? B. How is genetic “real estate” divvied up? C. What makes a good genetic “part”? What makes a good genome design? Questions for Today D. What is a standard biological part? E. What is reliable physical composition? And, reliable functional composition? F. How does synthetic biology relate to genetic engineering? ANNOUNCEMENT “A framework for programming integrated RNA devices” Christina Smolke, Small Western Trade School 4-5p today in 32-141 17. Last time we ended up considering the following sequence of DNA, the basic bio- logical functions encoded on the DNA, and whether or not this particular genetic archi- tecture might be “good” or “bad.” gc [atg cgcaa agggagg cgac {ATG gcaggttacggcgc taa] aggaatccgaaat TGA} aaa 18. It s hard for us to answer the question of good/bad architecture because we do not know (and perhaps, cannot know) the absolute purpose of this particular piece of DNA. What is the objective that nature has evolved this sequence to perform? If effi- ciency of encoding more or less important than modularity? Is a greater sensitiv- ity to mutations in the overlapping coding sequences good or bad? Cite as: Drew Endy. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. MIT 20.109 Module 1 Class 2 notes (DRAFT) 13 September 2007 19. Because the living world we inhabit is encoded by natural sequences of DNA (in- cluding ourselves), it is a hugely important to improve our understanding of the architec- ture of genetic systems....
View Full Document

This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

Page1 / 5

lec1_2 - MIT 20.109 Module 1 Class 2 notes (DRAFT) 13...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online