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Unformatted text preview: MIT 20.109 Module 1 Class 3 notes (DRAFT) 18 September 2007 Genome Engineering Drew Endy ( http://mit.edu/endy/ ) Questions Introduced Last Time D. What is a standard biological part? E. What is reliable physical composition? And, reliable functional composition? F. How does synthetic biology relate to genetic engineering? Discussion for Today F. How does synthetic biology relate to genetic engineering? G. Can we implement reliable physical and functional composition via standard biological parts? ANNOUNCEMENT “Genetic control of the synthesis and assembly of materials for electronics and energy” Angela Belcher, Mass Tech 4-5p today in 32-123 (food at 3:40p outside room) 34. How does synthetic biology relate to genetic engineering? People have long been interested in using biology to solve problems, from food and shelter, to drug production and biofuels, and now a wider number of applications, includ- ing building electronics, environmental monitoring and remediation, and perhaps even growing large-scale structures, like houses. About 30 years ago researchers discov- ered restriction endonucleases and invented recombinant DNA technology (rDNA). rDNA allows people to intentionally cut and paste pre-existing fragments of genetic ma- terial (so long as the restriction sites are in the right places!). This marked the begin- ning of “genetic engineering.” ( What does it mean to be an engineer? ) 35. About the same time the rDNA technology got invented, polymerase chain reaction (PCR) was figured out, with some of the foundational work being done here at MIT and then fully invented in the 1980s at Cetus, Inc. As important, by 1977, DNA sequencing was figured out by Fred Sanger at Harvard. Cite as: Drew Endy. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. MIT 20.109 Module 1 Class 3 notes (DRAFT) 18 September 2007 36. Taken together, rDNA, PCR, and DNA sequencing form a core set of underlying 36....
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.
- Spring '06