lec2_1 - Module 2: Expression Engineering 20.109 Lecture 1...

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Unformatted text preview: Module 2: Expression Engineering 20.109 Lecture 1 October 11th, 2007 Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. Is a butterfly collection a science experiment? Scientific Endeavors Images of butterfly collection and evolving hominid skulls removed due to copyright restrictions. Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. From Erren, T. C., et al. Comparing Neanderthal and Human Genomes. Science 315, no. 5819 (3 March, 2007): 1664. Charles Darwin was once asked if he thought that natural historians should collect data without the prejudice of a preformed hypothesis, or whether they should be observing nature with a particular theory in mind. In a stinging reply to friend, the economist Henry Fawcett, Darwin wrote that they may as well go into a gravel-pit and count the pebbles and describe the colors. Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. The dynamic proteome, not the static genome, determines an organisms phenotype. For instance, the caterpillar and tadpole share genomes with the butterfly and the frog, but their very different proteomes create very different organisms. Images removed due to copyright restrictions. Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. Eukaryotic Gene Expression Obstacles to expression Transcription Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. Courtesy of Arkitek Studios. Used with permission. Source: RNAi Interface animation for nature.com ( http://www.nature.com/focus/rnai/animations/index.html) Eukaryotic Gene Expression mRNA processing Export Translation Cite as: Natalie Kuldell. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY]. Courtesy of Arkitek Studios. Used with permission....
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lec2_1 - Module 2: Expression Engineering 20.109 Lecture 1...

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