lecture08

lecture08 - 20.106J Systems Microbiology Lecture 8 Prof....

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20.106J – Systems Microbiology Lecture 8 Prof. DeLong ¾ Chapter 8 – Brock: Regulation of Cell Activity ¾ Note from a problem on the test: when O 2 is not the terminal electron acceptor, alternative electron acceptors are used: NO 3 , SO 4 , Fe 3. ¾ When you split C 6 H 12 0 6 in this manner, you get CO 2 and ethanol, H 2 . Fermentation – no electron transport chain. ATP made by substrate level phosphorylation. ¾ Next week: we’ll start going into genetics, and a history of genetics. ± Turning genes on and off: transcriptional control ± Regulation of prokaryotic transcription. o Single-celled organisms have pretty short doubling times – this helps them respond quickly o The half-life of most mRNAs is short (on the order of a few minutes). o Transcription and translation are coupled in a single cellular compartment o Genes are regulated in units called operons. All of the genes necessary for a particular function are generally located on the same operon with the same promoter. ± This allows uniform control of biosynthetic pathways. o Alternate Sigma factors. There are different ones to use depending on where the cell is in its growth cycle. ± The use of different sigma factors also varies by organism.
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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lecture08 - 20.106J Systems Microbiology Lecture 8 Prof....

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