lecture09

lecture09 - 20.106J Systems Microbiology Lecture 9 Prof...

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20.106J – Systems Microbiology Lecture 9 Prof. DeLong ¾ Elena & Lanski, National Review Genetics 4:457 ¾ Marx et al. Flux Analysis ¾ For next lecture: Guest speaker Prof. Chris Marx from Harvard o Freezing generations of E. coli o Genetic material is not static – it’s changing all the time. While it is preserved over time, there are also evolutionary mechanisms to automatically create variability. ¾ To cover today: Genetic Exchange in Bacteria o Homologous recombination ± Promiscuous genetic exchange o Transformation o Plasmids and conjugation o Transposable elements o Transduction (virus mediated exchange) ± Three main mechanisms of gene exchange in bacteria: o Transformation ± Extracellular DNA uptake ± This was important historically in the discovery of what DNA actually is ± DNA that’s taken up can be used in different ways o Conjugation ± Bacterial mating systems ± This often involves pili o Transduction ± Virally mediated gene exchange ± Slide: RecA mediated homologous recombination
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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lecture09 - 20.106J Systems Microbiology Lecture 9 Prof...

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