MIT20_020S09_prj6_hepc_3id

MIT20_020S09_prj6_hepc_3id - BY Jenny zhou Leanna morinishi...

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Unformatted text preview: BY Jenny zhou Leanna morinishi Samira daswani THREE IDEAS PRESENTATION: OOSTING THE BODY THE THREE IDEAS 1. BACTERIAL INFECTIONS 2. PRIONS 3. VIRAL INFECTIONS Introduction Increasing defenses of the body ! The three broad categories of infectious agents: Bacteria, Prions and Viruses We chose these topics because regardless of the infecting agent, we want to treat the body to overcome the disease in the early stages BACTERIAL INFECTION Bacteria are everywhere ! Some good and some bad ! The bad ones cause widespread diseases ! Bacteria cause endemic, epidemic and pandemic infectious diseases ! Find the cure to one = Finding possible cures to others ! Tackling Bacteria: Why it will help Many of the sicknesses we get today are still bacteria related. The Centers for Disease Control and Prevention lists over 20 bacteria related diseases that are still major concerns. Diseases like meningitis and pneumonia still kill people. By making the body more able to fight off bacterial infections, we would be helping to eradicate a major health concern. Things We Can Target Flagella Long, thin filaments on the cell surface that enable bacteria to move. Spores Dormant form that enable bacteria to survive when environmental conditions are difficult. Capsules Helps prevent white blood cells from ingesting these encapsulated bacteria. Biofilm A secreted substance that helps them attach to other bacteria, cells, or objects. Outer Membrane Gram negative bacteria have an outer membrane that protects them against certain antibiotics. When this membrane is breached, it releases endotoxins. Antibiotic Resistance Genes that encode for drug resistance can be passed to later generations or even other species of bacteria Streptococcus Gram positive bacteria High amount of peptidoglycan in the cell wall Lack the outer membrane seen around gram negative bacteria Occur in chains Nonmotile Nonsporeforming Adhesins Hyaluronic acid capsule M Proteins Image removed due to copyright restrictions. Structure of gram positive and gram negative bacterial cell walls. http://www.sigmaaldrich.com/etc/medialib/life- science/biochemicals/migrationbiochemicals1/Bacterial_Cell_Lysis.Par.0001.Image.569.gif Streptococcus Expresses streptolysin s on its surface Which kills the white blood cell through necrosis, a death in which the cell swells and eventually bursts Cause lytic granules (lysosomes) of the white blood cell to be emptied into the WBC's cytoplasm instead of on the bacteria Streptococcus pyogenes (Class A) causes strep throat, rheumatic fever Streptococcus agalactiae (Class B) causes bacterial pneumonia, meningitis http://www.textbookofbacteriology.net/streptococcus.html http://www.textbookofbacteriology.net Images of Streptococcus pyogenes removed due to copyright restrictions....
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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MIT20_020S09_prj6_hepc_3id - BY Jenny zhou Leanna morinishi...

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