MIT20_020S09_prj10_neuro_sp

MIT20_020S09_prj10_neuro_sp - Immunoliposome directed drug...

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Unformatted text preview: Immunoliposome directed drug delivery Alzheimer’s lowers quality of life Importance of memory Longer life (Alzheimer’s is ultimately fatal) An estimated 26.6 million people 65 years and older had Alzheimer’s worldwide in 2006 • Strong correlation between Alzheimer’s and beta-amyloid plaques • Causes neural degeneration • Beta amyloid protein vs. beta pleated sheets Image removed due to copyright restrictions. component of Alzheimer’s ◦ Beta-amyloid protein Reduce neural damage ◦ By inhibiting the formation of plaques To target a speciFc Figure by MIT OpenCourseWare. A polyphenol with many antioxidant properties found in many plants • Binds to BA precursor protein, prevents it from taking final shape with its potent iron chelating abilities Goes to brain Immunoliposomes Attaches to BA precursor protein Releases EGCG Beta-Amyloid Precursor Protein Liposome Antibody Bacteria (E. coli) EGCG Beta- Amyloid Binding Site Input Output Y Y Y Modified antibodies detect beta‐amyloid plaques Immunoliposomes containing EGCG Feedback system: based on concentration of plaques Drug Delivery Device -Immunoliposome Input Output Beta-amyloid Detector -Receptor sequence on antibody Trigger Input Output -Release of EGCG Stop/Feedback Mechanism -Large amount of EGCG inhibits production of EGCG Input Output B-A Protein B-A Detector Binding B-A Binding Trigger Release EGCG Excess EGCG Negative Feedback Inhibition DDD...
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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MIT20_020S09_prj10_neuro_sp - Immunoliposome directed drug...

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