MIT20_020S09_prj12_neuro_td

MIT20_020S09_prj12_neuro_td - Sleepaway Parts PARTS...

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Sleep away
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Parts PARTS Liposome DSPE-PEG Monoclonal Antibody OX26 Adenosine Deaminase 608958 Adenosine Receptor ADORA1 Transcription Terminators TL1 Promoter PEC3786 Receptor-Associated Protein of Synapse RAPSN We can produce these system parts through genetic modification of e. coli bacteria
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Time Diagram A A C B C B Immunoliposomes enter brain. . Receptors attach to extracellular adenosine Immunoliposome opens, releases system. Drug Delivery Device Receptors ADA D ADA breaks down adenosine held in receptors D
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General System Diagram Immunoliposomes Immunoliposomes enter brain Releases the receptors and enzymes
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Device Diagram Enzymes and receptors will capture and break down adenosine Immunoliposome containing the enzyme and receptors
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Testing y Testing parts in vitro ¬ Testing system in vivo y Immunoliposome ¬ Trials with mice ± Drug delivery system ± attaching antibodies ± Side effects of system ± inserting receptors and components enzyme ± Side effects of delaying sleep y Adenosine ¬ Trials with humans attachment to ± Similar steps receptor y Effectiveness of ADA
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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MIT20_020S09_prj12_neuro_td - Sleepaway Parts PARTS...

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