MIT20_020S09_prj19_onco_sp

MIT20_020S09_prj19_onco_sp - Image: Growth factor...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Image: Growth factor stimulated human breast cancer cells stained for actin (blue), nuclei (green) and the Golgi apparatus (purple). Courtesy of Torsten Witmann. Used with permission. Used Tech Spec Review Anonymous students MK & NM MK DESIGN LOGISTICS ISSUES The “What?” Tech Spec Review Tech • added cells mark cancer in metastasis • lights up near tumors The “How?” The “Why?” The • use dual signaling to • possibility of killing tumor cells • signals production of light •shows tumor cells moving • main cause of death indicate metastasis DESIGN MMP-1 MMP-1 MMP MMP SENSOR SENSO SIGNAL SIGNAL PRODUCER PRODUCER COX-2 COX-2 LOGISTICS COX COX SENSO SENSOR LIGHT LIGHT PRODUCER PRODUCER ISSUES DESIGN DESIGN LOGISTICS ISSUES SIGNAL SIGNAL PRODUCER PRODUCER LUCIFERASE ANTIBODIES RECEPTOR DESIGN MMP-1 MMP-1 LOGISTICS ISSUES MMP MMP SENSOR SENSOR Courtesy of RCSB.org Source: Chung, L., et al. "Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis." The EMBO Journal 23 (2004): 3020-3030. Courtesy of Hideaki Nagase. Used with permission. DESIGN MMP-1 MMP-1 LOGISTICS MMP MMP SENSOR SENSOR ISSUES DESIGN MMP-1 MMP-1 LOGISTICS MMP MMP SENSOR SENSOR ISSUES DESIGN COX-2 COX-2 LOGISTICS COX COX SENSOR SENSOR Image removed due to copyright restrictions. ISSUES DESIGN COX-2 COX-2 LOGISTICS COX COX SENSOR SENSOR ISSUES DESIGN LOGISTICS SIGNAL SIGNAL PRODUCER PRODUCER ISSUES DESIGN LOGISTICS ISSUES LIGHT LIGHT PRODUCER PRODUCER Image removed due to copyright restrictions. Photo of a glowing insect. DESIGN LOGISTICS LIGHT LIGHT PRODUCER PRODUCER ISSUES DESIGN DESIGN LOGISTICS ISSUES DESIGN LOGISTICS ISSUES Image removed due to copyright restrictions. Diagram with caption “freezefracture splits membrane.” HTTP://WWW.BIOLOGICALPROCEDURES.COM/ HTTP://WWW.BIOLOGICALPROCEDURES.COM/ DESIGN DESIGN LOGISTICS ISSUES DESIGN DESIGN LOGISTICS ISSUES DESIGN LOGISTICS ISSUES Image removed due to copyright restrictions. Artist’s rendering of breast cancer metastasis at http://www.topcancernews.com/news/20 73/breast-cancer-metastasis-could-bepredicted.html Tech Spec Review Tech Final Decision? • several uncertainties • however, experimentation leads to insight on workings of metastasis • worth exploring YES! MIT OpenCourseWare http://ocw.mit.edu 20.020 Introduction to Biological Engineering Design Spring 2009 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms. ...
View Full Document

This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

Ask a homework question - tutors are online