MIT20_020S09_prj20_onco_td - Anonymous MIT students MK and...

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Anonymous MIT students MK and NM Natalie Kuldell 20.020 13 May 2009 Technical Document: oncoCURES Problem: Dynamic Metastasis Imaging Our project has been designed with the hope of creating a way to detect early metastasis in cancerous cells. We hope to not only use this as a detection method for medicinal purposes and a way to allow early treatment of metastatic cells, but also for research. We could use this process to better understand the mechanisms that drive metastasis and where these new cancer cells travel in the body. Not much is known currently on why metastasis happens where it does and if there is some correlation for where it happens within the original tumor. By imaging this system in 3D and great detail over a selected time frame, we will get a sense of the systems dynamics. Another hope is that parts in our system might be reused in for other systems that could lead to successfully targeting and killing cancer cells in metastasis. The modularity of our selected ribozyme in use allows for changes in reactions to the metastasis cell, whether it is detection through light and magnetic compounds, or direct attack on the cells being targeted. Competition: Static Tests and Ambiguous Results The main competition that our system faces is the assortment of available static tests that give a positive or negative to the presence of metastasis at only one point in time. These tests include CTC/TMEM blood tests and lymph node screening. Most of these test the surrounding area for mutations in the blood or lymph which is the end result of metastasis. For instance, CTC or circulating tumor cells can be screened for by testing the blood and seeing if a high concentration is present. The problems with these test is that they only test if there was or was not metastasis at a particular time and do not allow for much accuracy. The “yes or no” answer at the time with high failure rates does not promote much understanding of the metastasis itself. These tests are also not very efficient and still take time to complete. System Description: The Detector T Cell Our system is a straightforward one with relatively few parts. Our system is an engineered T cell taken from the patients themselves in order to reduce risk of an immune response that may clear our cell from the system. This engineered cell will pick up on two signals that are known to indicate two enzymes that are overexpressed during metastasis. Collagen “debris” will enter into the cell via a collagen receptor which causes endocytosis. Collagenases such as MMP 1 are overexpressed in metastatic growth since the cancer must first break away from the basement membrane by degrading the extracellular matrix into collagen fragments. We also sense the prostanoid production, which is
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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MIT20_020S09_prj20_onco_td - Anonymous MIT students MK and...

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