MIT20_020S09_proj_hepc_fin

MIT20_020S09_proj_hepc_fin - Image by MIT OpenCourseWare. A...

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HEPATITIS C By Jenny Zhou Leanna Morinishi Samira Daswani A TREATMENT FOR HEPATITIS C Image by MIT OpenCourseWare.
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Introduction ± What does the liver do? ± Hepatitis C : Infection of the liver causing cirrhosis. Figure by MIT OpenCourseWare.
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Importance of disease ± WHO labeled it a "silent" epidemic. ± Affects at least 4 million people in the U.S. and 175 million people worldwide. ± HCV infects 4 times more people in the US than HIV ± Leading cause for liver cancer
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What is HCV? http://www.the-scientist.com/article/display/24827/ Image by MIT OpenCourseWare.
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Chimp study ± Overview ± Nucleoside analog with robust HCV antiviral effect ± 2’C- 7- Deaza Methyladenosine ± Specifically inhibits viral RNA- dependent RNA- polymerase ± Dosage (.2-2 mg per kg/day intravenous) ± Treatment length (7 days) ± Results (significant decrease in viral load)
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Why we chose this study? ± Robust drop in viral load using non-toxic doses of nucleosides. ± Nucleoside specific to viral RNA polymerase ± Method tested in vivo in human-like species Image courtesy of Ori2uru on Flickr.
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Improve nucleoside therapy ± What was wrong with the treatment? Low nucleosides uptake
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HCV targeting mechanism: http://www.the-scientist.com/article/display/24827/ Image by MIT OpenCourseWare.
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Virus targets the liver: Image removed due to copyright restrictions. Figure 2, “Current model for hepatitis C virus (HCV) entry.” In Moradpour, D., F. Penin, and C. M. Rice. “Replication of hepatitis C virus.” Nature Reviews Microbiology 5 (June 2007): 453-463. DOI:10.1038/nrmicro1645
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NETL : N ucleoside E ncapsulated T argeted L iposomes Systems diagram:
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Figure by MIT OpenCourseWare. Figures by MIT OpenCourseWare.
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Timing diagram – In Vivo Delivery to Liver Recognition Endocytosis Release of Nucleosides Viral RNA Inhibition
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production
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MIT20_020S09_proj_hepc_fin - Image by MIT OpenCourseWare. A...

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