mod3_blue - Expression of dsRNA in Spirogyna algae to...

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KAT PAK AND MATTHEW LOPER 20.109 FINAL PRESENTATION DECEMBER 7, 2007 Expression of dsRNA in Spirogyna algae to inhibit development of Malaria carrying mosquitoes Cite as: Angela Belcher, Drew Endy, Natalie Kuldell and Agi Stachowiak. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].
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Malaria y Caused by Plasmodium protozoan parasites { Once a host is infected, the parasite remains indefinitely y Infects 515 mil people a year and kills between 1 and 3 million including South America, Africa, India, Asia, and the Middle East Map from Wikiped i a, using 2003 data from U.S. CDC. Cite as: Angela Belcher, Drew Endy, Natalie Kuldell and Agi Stachowiak. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].
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Malaria y Associated with poverty and possible huge hindrance to economies y Estimated $12B malaria economic costs in Africa per year 1. Sachs J, Malaney P (2002). "The economic and social burden of malaria". Nature 415 : 680-5. Image courtesy of “ dosh dosh .” Cite as: Angela Belcher, Drew Endy, Natalie Kuldell and Agi Stachowiak. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].
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Anopheles mosquitoes: A deadly vector y Female Anopheles mosquitoes primary Plasmodium carrier y Larvae hatch and feed on Spirogyna algae 2 y Grow and develop to into pupa and become adults 2 . Rejmankova, E. H. et al. 1993 Environmental and regional determinants of Anopheles (Diptera: Culicidae) larval distribution in Belize, Central America. Environ. Entomol. 22, 978–992. Courtesy of US CDC. Cite as: Angela Belcher, Drew Endy, Natalie Kuldell and Agi Stachowiak. Course materials for 20.109 Laboratory Fundamentals in Biological Engineering, Fall 2007. MIT OpenCourseWare (http://ocw.mit.edu), Massachusetts Institute of Technology. Downloaded on [DD Month YYYY].
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Malaria: Current Treatments y No effective, approved vaccine { Huge amount of research being done to discover effective vaccines { Current drugs not affordable or practical for chronic use in malaria regions {
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