pi_lec1 - 20.181 Lecture 1 Topics 1 Phylogenetic Inference...

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20.181 Lecture 1 Topics 1. Phylogenetic Inference 2. Molecular Modeling / Protein Design 3. Metabolic Network Modeling & Design Underlying Relationship Each Topic has the following components: 1. Data structure 2. Optimization problem 3. Algorithms Grading 1. HW @ 60% 2. 3 in-class exams at 30% total 3. Class Participation @ 10% HW Due Dates HWs are due before midnight 1 week after they are given Phylogenetic Inference 1. What is phylogenetic inference? o Phylogenetic inference if the inference of phylogeny (how's that for a self- referential definition)? o Let's try again. Phylogenetic Inference (PI) is the figuring out the family relationship of a set of genetic sequences. o Answers.com weighs in. o PI is used to figure out what's what given an otherwise uncharacterized stretch of DNA sequence. For example, if you've just sequenced the genome of a new organism then you would use phylogenetic inference to attempt to figure out what the organism was related to and thus better understand the thing you've just sequenced. 2.
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pi_lec1 - 20.181 Lecture 1 Topics 1 Phylogenetic Inference...

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