ps3 (1) - Systems Microbiology 1.084J/20.106J PROBLEM SET...

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Systems Microbiology 1.084J/20.106J PROBLEM SET #3 – Due Monday Oct. 23 rd Problem 3.1 a. Describe the stringent response, and at what level and what components of cellular activity it regulates. b. Most biosynthetic operons need only be under negative control for effective regulation, while most catabolic operons need to be under both negative and positive control. Why might this be? c. Why are promoters from E. coli under positive control not close matches to the promoter consensus sequence for E. coli ? d. The attenuation control of some of the pyrimidine biosynthetic pathway genes in E. coli actually involves coupled transcription and translation. Can you propose a mechanism whereby the cell could somehow make use of translation to help it measure the level of pyrimidine nucleotides? e. How could quorum sensing be considered a regulatory mechanism for conserving cell resources? Problem 3.2 a. How does homologous recombination differ from site-specific recombination? b.
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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