pset8 - BE.011/2.772 Homework Week of April 12, 2004 2....

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BE.011/2.772 Homework Week of April 12, 2004 2. Integrins are a family of transmembrane receptors that mediate adhesion between cells and extracellular matrix by binding to specific ligands in extracellular matrix molecules, and then linking to the cytoskeleton inside the cell to form a continuous physical bridge. When blood platelets are activated, the integrin a IIb β 3 on the surface of the platelets binds to peptide sequences containing the sequence RGD (Arg-Gly-Asp) in the molecule fibrinogen. Upon binding to ligand, the integrins are driven to cluster together, facilitating strong adhesion and degranulation of platelets, resulting in clot formation. Clot formation in blood vessels can have severe pathophysiological consequences, including stroke and embolism, and thus drugs that inhibit integrin-mediated functions on platelets are now being developed. One drug, Integrilin, is a small soluble peptide that binds to the integrin and blocks binding to fibronectin. a
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This note was uploaded on 11/11/2011 for the course BIO 20.010j taught by Professor Lindagriffith during the Spring '06 term at MIT.

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pset8 - BE.011/2.772 Homework Week of April 12, 2004 2....

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