What is the mechanism of lubrication of artificial

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Unformatted text preview: joints? • Does injection of hyaluronic acid help the patient with osteoarthritis, and if so, would osteoarthritis, it help the total joint replacement patient? HA INJECTION FOR THE TREATMENT OF OSTEOARTHRITIS • Does not reverse the degenerative changes of OA. • Cannot yet determine if it slows progression. • Has an analgesic effect that mimics NSAIDs and steroid injection – placebo effect? • Affects lubricity of the joint? Page 19 HYALURONIC ACID HYALURONIC (provides the viscosity in synovial fluid*) • A long chain polymer with a molecular weight between 106 and 107 produced by synovial cells. • At low molecular weight (< 106) and concentration (< 1 mg/ml), HA molecules form random coils, and do not interlock with each other (lower viscosity). • At higher molecular weight and concentration, HA chains interlock to form an entanglement network that has a high viscosity. * May require interaction with proteins in joint fluid. HA INJECTIONS FOR THE TREATMENT OF OSTEOARTHRITIS • The half-life of HA in the joint is less than 24 halfhours. • The lasting effect...
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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