exam2 - Take-Home Exam 2 05/02/06 80 points total...

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20.462J/3.962J S06 EXAM 2 1 of 2 9/5/06 Take-Home Exam 2 20.462J/3.962J 05/02/06 Spring 2006 80 points total Uploaded on the MIT server are 4 journal articles related to the problem of oral vaccination: 1. Neutra and Kozlowski, ‘Mucosal vaccines: the promise and the challenge,’ Nat. Rev. Immunol . 6 148-158 (2006) 2. Keegan and Saltzman, ‘Biomimetic design in microparticulate vaccines,’ Biomaterials 24 4435-4443 (2003) 3. Mutwiri et al., ‘Microparticles for oral delivery of vaccines,’ Expert Opin. Drug Deliv . 2 (5) 791- 806 (2005) 4. Frey et al. ‘Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: Implications for microbial attachment and oral vaccine targeting,’ Journal of Experimental Medicine 184 1045-1059 (1996) Using these references as a starting point, we will critique a novel strategy for oral immunization against rotavirus, an intestinal pathogen, using a recombinant protein antigen. The immunization
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exam2 - Take-Home Exam 2 05/02/06 80 points total...

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