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Unformatted text preview: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Department of Electrical Engineering and Computer Science, Department of Mechanical Engineering, Division of Bioengineering and Environmental Health, Harvard-MIT Division of Health Sciences and Technology Quantitative Physiology: Cells and Tissues 2.791J/2.794J/6.021J/6.521J/BE.370J/BE.470J/HST.541J Hodgkin-Huxley Project This theoretical project is intended to provide an opportunity to learn about the complex behav- iors that can be exhibited by the Hodgkin-Huxley model and to compare behaviors of the model with behaviors of electrically excitable cells. We have two simulations. The first models a space- clamped axon. That model generates membrane action potentials. The second models an axon without space-clamp (although the second model can simulate a space clamp since the longitudi- nal resistances can be set to zero). The second model can produce propagated action potentials. The second model can be used to explore a wider range of phenomena than the first. The first model is faster and simpler than the second. Thus both models are useful, and your project can use either or both of the models. Students are STRONGLY encouraged to work in pairs, however, individual projects will be approved if there are extenuating circumstances. If a pair of students collaborate on a project they should submit a single proposal and a single report which identifies both members of the team and gives both email addresses. Proposals should be submitted via the form available on the MIT s e rver . Proposals will be returned as soon as possible so that students can revise them. Only the final, accepted proposal will be given a grade. The demonstration project performed in lecture on the effect of temperature cannot be the basis of a student project. Practical considerations in the choice of a topic Projects can involve almost any of the properties of the Hodgkin-Huxley model. However, to avoid projects whose aims are vague (e.g., I would like to understand how the Hodgkin-Huxley model works) the proposed project should be in the form of a specific and testable hypothesis. Projects that involve months of computation should obviously be avoided. The amount of computation time should be explicitly taken into account in planning a project. For example, any project that involves measuring the threshold of occurrence of an action potential for many different parameter values is bound to be very time consuming, because determining the threshold for a single set of parameters itself involves many computations. The task is to choose a physiological property of the excitation of the action potential that is of interest, and then to define a specific, feasible project....
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.
- Fall '06