l21_case_sdy_omp

l21_case_sdy_omp - 20 .201 Lecture # 21 11/09/05 Page 1...

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Unformatted text preview: 20 .201 Lecture # 21 11/09/05 Page 1 Lecture # 21 : Omeprazole Case Study November 9, 2005 20 .201 Mechanisms of Drug Action 20 .201 Lecture # 21 11/09/05 Page 2 http://hopkins-gi.org/multimedia/database/intro_247_Parietal.swf Gastric physiology Acid Secretion Pathways Images of Acetylcholine Pathways, Gastrin Pathways, Histamine Pathways removed due to copyright restrictions. 20 .201 Lecture # 21 11/09/05 Page 3 R/S-Omeprazole (20 mg) Esomeprazole (20 mg) V d Plasma t 1/2 Albumin binding Peak Conc. (C max ) CL total CL int (liver microsomes) 42.6 14.6 5 d in AUC 49% 111% Oral availability 53% 89% Urinary Excretion <1% <1% 0.34 L/kg 16 L 0.7 hr 1.2 hr 95% 97% EM = 0.6-0.7 M PM = 3.5 M EM = 1.7 M 7.5 mlmin-1 mg-1 PKs of Omeprazole vs. Esomeprazole 20 .201 Lecture # 21 11/09/05 Page 4 Metabolism of omeprazole and esomeprazole N N HN S O OCH 3 CH 3 H 3 C OCH 3 O N N H N S O OCH 3 CH 3 H 2 C H 3 CO HO N N H N S O OCH 3 CH 3 H 3 C H 3 CO Omeprazole 5-Hydroxyomeprazole...
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l21_case_sdy_omp - 20 .201 Lecture # 21 11/09/05 Page 1...

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