lecture1

lecture1 - 3.051J/20.340J Lecture 1: Intro. to...

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1 3.051J/ 20 .340 J Lecture 1: Intro. to Biomaterials: Structural Hierarchy in Materials & Biology What are “biomaterials”? A good working definition from the text is: A nonviable material used in a medical device, intended to interact with biological systems .”* MEDICAL DEVICE EXAMPLES ANNUAL # (U.S.)* Sutures (temporary or bioresorbable) 250 M** Catheters (fluid transport tubes) 200 M Blood Bags 40 M Contact Lenses 30 M Intraocular Lenses 2.5 M Coronary Stents 1.2 M*** Knee and Hip Prostheses 0.5 M Breast Prostheses (cancer or cosmetic) 0.25 M Dental Implants 0.9 M Renal Dialyzers (patients) 0.3 M Oxygenators/CPB’s (cardiopulmonary bypass system— 0.3 M facilitates open heart surgery) Vascular Grafts 0.3 M Pacemakers (pulse generators) 0 . 4 M Biomaterials are defined by their application, NOT chemical make-up Ex. Intraocular lenses Composition: poly(methyl methacrylate) PMMA, a.k.a. “acrylic” Properties: High refractive index Used as auto Easily processed taillight covers for the same reasons! Environmentally stable (relatively inert) Good mechanical properties *from Biomaterials Science: An Introduction to Materials in Medicine, 2 nd ed., B.D. Ratner et al., eds., Elsevier, NY 2004 **from Biomaterials Science: An Introduction to Materials in Medicine, 1st ed., B.D. Ratner et al., eds., Elsevier, NY 1996 ***from Introduction to Biomedical Engineering, 2 nd ed., J. Enderle et al,, eds., Elsevier, NY 2005
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2 3.051J/ 20 .340 J Biomaterials cover all classes of materials – metals, ceramics, polymers PLA = polylactide PGA= polyglycolide PDO=poly(p-dioxanone) PUR = polyurethane ePTFE = expanded polytetrafluoroethylene polyethylene PET=polyethylene terephthalate Ear: HA, Al 2 O 3 , Ti, silicone Ti, Ti-Al-V, Al 2 O 3 , HA, Bioglass acrylic 2 O 3 , HA, TCP, HA/PLA, Bioglass, Ti, Ti-Al-V Cranial: 316L SS, Ti, acrylic, HA, TCP Blood vessels: ePTFE, PET C, ePTFE, PET, PUR PLA, PGA, PCL, PTMC, PDO Ocular lenses: acrylates, silicone Bone Fixation: 316L SS, Co-Cr-Mo, Ti, Ti-Al-V, PLA/HA., PLA, PGA Load-bearing Orthopedic: Al 2 O 3 , Zirconia, 316L SS, Ti, Ti-Al-V,
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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lecture1 - 3.051J/20.340J Lecture 1: Intro. to...

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