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lecture4 - 1 3.051J/20.340J Lecture 4 Biomaterials Surfaces...

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1 3.051 J / 20 .340 J Lecture 4 Biomaterials Surfaces: Chemistry Like metallic implants, some polymers used in biomaterials applications are susceptible to chemical reactions that lead to degradation through hydrolysis. In many cases, a polymer is specifically chosen for its ability to degrade in vivo. Polymer Hydrolysis Polymer hydrolysis involves the scission of susceptible molecular groups by reaction with H 2 O. ¾ May be acid, base or enzyme catalyzed ¾ Not surface-limited if water penetrates bulk a) Molecular & Structural Factors Influencing Hydrolysis ¾ Bond Stability ¾ Hydrophobicity: hydrophobicity hydrolysis ¾ MW & architecture: higher MW hydrolysis ¾ Morphology crystallinity hydrolysis porosity hydrolysis ¾ T g : less mobility hydrolysis Bond Stability Susceptible linkages at bonds where resonance stabilized intermediates are possible… O O Esters : R- C -O-R’ + H 2 O R- C -OH + HO-R’
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2 3.051 J / 20 .340 J
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