lecture4

lecture4 - 1 3.051J/20.340J Lecture 4 Biomaterials...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 3.051 J / 20 .340 J Lecture 4 Biomaterials Surfaces: Chemistry Like metallic implants, some polymers used in biomaterials applications are susceptible to chemical reactions that lead to degradation through hydrolysis. In many cases, a polymer is specifically chosen for its ability to degrade in vivo. Polymer Hydrolysis Polymer hydrolysis involves the scission of susceptible molecular groups by reaction with H 2 O. ¾ May be acid, base or enzyme catalyzed ¾ Not surface-limited if water penetrates bulk a) Molecular & Structural Factors Influencing Hydrolysis ¾ Bond Stability ¾ Hydrophobicity: hydrophobicity hydrolysis ¾ MW & architecture: higher MW hydrolysis ¾ Morphology crystallinity hydrolysis porosity hydrolysis ¾ T g : less mobility hydrolysis Bond Stability Susceptible linkages at bonds where resonance stabilized intermediates are possible… O O Esters : R- C -O-R’ + H 2 O R- C -OH + HO-R’
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 3.051 J
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

Page1 / 6

lecture4 - 1 3.051J/20.340J Lecture 4 Biomaterials...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online