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lecture9 - 3.051J/20.340J 1 Lecture 9 Surface Modification...

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1 3.051 J / 20 .340 J Lecture 9: Surface Modification of Biomaterials Purpose : alter surface properties to enhance performance in biological environment while retaining bulk properties of device Specific Objectives: 1. clean a surface 2. reduce/eliminate protein adsorption reduce undesirable/uncontrolled responses to implants & extracorpeal devices C3b/IgG adsorption activation of WBCs reduce nonspecific adsorption on biosensors & bioassays Source: Wikipedia (Gray's Anatomy) (noise & fouling) current strategy: hydrated, hydrophilic surfaces PEO is current “gold standard” 3. reduce/eliminate cell adhesion create surfaces that mimic nature’s cell resistant surfaces ex. Human serum albumin: naturally low affinity to components of body fluids & tissues ( consider its high conc. in blood—60 wt% of proteins! )
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2 3.051 J / 20 .340 J 4. reduce thromogenicity hydrophilic surfaces - eliminate protein adsorption hydrophobic surfaces - inherently weak surface/cell interface - exploits shear stress due to blood flow
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