lecture9_2

lecture9_2 - Lecture 9 Surface Modification of Biomaterials...

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Lecture 9: Surface Modification of Biomaterials Supporting notes 3.051J/20.340J Materials for Biomedical Applications, Spring 2006 1
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Purpose: Alter surface properties to enhance performance in biological environment while retaining bulk properties of device The modified zone at the surface of the device should be as thin as possible . Ideally < 1 nm 2
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Specific objectives: 1. Clean a surface 2. Reduce/eliminate protein adsorption 3. Reduce/eliminate cell adhesion 4. Reduce bacterial adhesion 5. Reduce thrombogenicity 6. Promote cell attachment/adhesion 7. Alter transport properties 8. Increase lubricity 9. Increase hardness 10. Enhance corrosion/degradation resistance 3
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Preparation of non-fouling surfaces to prevent non-specific protein/cell or bacterial adhesion to reduce thrombogenicity Surfaces should be hydrophilic or very hydrophobic. 4 Figure by MIT OCW.
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Example of “gold standard” Surface modification with PEO derivative. PEO-PPO-PEO, Pluronic Chemical immobilization Physical adsorption Short-time use Long-time use Ex. Drug delivery 5
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Physical adsorption - - - - Other strategies for hydrophilic surfaces 1
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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lecture9_2 - Lecture 9 Surface Modification of Biomaterials...

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