Unformatted text preview: Nat Struct Biol. 2003 Jan;10(1):59-69. Evolutionarily conserved networks of residues mediate allosteric communication in proteins. Suel GM, Lockless SW, Wall MA, Ranganathan R. What does allosteric mean? What strategy do the authors use to find residues important for long range communication for the protein families they are studying? The authors comment that their findings are consistent with the fact that mutations at many positions in a protein usually cause no abnormal phenotype, but mutations in a few residues result in severe phenotypes. Briefly explain there comment....
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.
- Fall '06
- Systems Biology