lit_disc_quiz_1 - Nat Struct Biol 2003 Jan;10(1:59-69...

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7.91/BE.490: Foundations of Computational and Systems Biology Literature Discussion Quiz #1 Due 2/19/04 at the beginning of class Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4285-8. Assigning protein functions by comparative genome analysis: protein phylogenetic profiles. Pellegrini M, Marcotte EM, Thompson MJ, Eisenberg D, Yeates TO. What do the authors define as ‘functionally linked’ proteins? Briefly explain how the authors intend to assign function to previously uncharacterized proteins. What method do they use for analyzing protein phylogenetic profiles? What are the main findings or conclusions of the paper?
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Unformatted text preview: Nat Struct Biol. 2003 Jan;10(1):59-69. Evolutionarily conserved networks of residues mediate allosteric communication in proteins. Suel GM, Lockless SW, Wall MA, Ranganathan R. What does allosteric mean? What strategy do the authors use to find residues important for long range communication for the protein families they are studying? The authors comment that their findings are consistent with the fact that mutations at many positions in a protein usually cause no abnormal phenotype, but mutations in a few residues result in severe phenotypes. Briefly explain there comment....
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.

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