Unformatted text preview: How did they identify putative regulatory motifs? Explain briefly. Paper #2 Computational identification of noncoding RNAs in E. coli by comparative genomics. Curr Biol. 2001 Sep 4;11(17):1369-73. Computational identification of noncoding RNAs in E. coli by comparative genomics. Rivas E, Klein RJ, Jones TA, Eddy SR. The authors perform a computational comparative genomic screen for ncRNA genes. What kind of mutations that usually occur in ncRNAs do they take advantage of? Why do these kinds of mutations often appear in ncRNA genes? Briefly describe the approach they use to identify ncRNAs in E. coli. How do the authors test their predictions? What are the problems with this approach?...
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This note was uploaded on 11/11/2011 for the course BIO 2.797j taught by Professor Matthewlang during the Fall '06 term at MIT.
- Fall '06
- Systems Biology